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| Light Therapy Studies & Articles |
NASA Light Emitting Diode Medical Applications From Deep Space to Deep Sea
Abstract: This work is supported and managed through the NASA Marshall Space Flight
Center - SBIR Program. LED-technology developed for NASA plant growth experiments in
space shows promise for delivering light deep into tissues of the body to promote wound
healing and human tissue growth. We present the results of LED-treatment of cells grown
in culture and the effects of LEDs on patients’ chronic and acute wounds. LED-technology
is also biologically optimal for photodynamic therapy of cancer and we discuss our
successes using LEDs in conjunction with light-activated chemotherapeutic drugs.
Abstract: This work is supported and managed through the NASA Marshall Space Flight
Center - SBIR Program. LED-technology developed for NASA plant growth experiments in
space shows promise for delivering light deep into tissues of the body to promote wound
healing and human tissue growth. We present the results of LED-treatment of cells grown
in culture and the effects of LEDs on patients’ chronic and acute wounds. LED-technology
is also biologically optimal for photodynamic therapy of cancer and we discuss our
successes using LEDs in conjunction with light-activated chemotherapeutic drugs.
Medical Applications of Space Light-Emitting Diode Technology - Space Station and Beyond
Abstract: Space light-emitting diode (LED) technology has provided medicine with a new
tool capable of delivering light deep into tissues of the body, at wavelengths which are
biologically optimal for cancer treatment and wound healing. This LED technology has
already flown on Space Shuttle missions and shows promise for wound healing applications
of benefit to Space Station astronauts.
Abstract: Space light-emitting diode (LED) technology has provided medicine with a new
tool capable of delivering light deep into tissues of the body, at wavelengths which are
biologically optimal for cancer treatment and wound healing. This LED technology has
already flown on Space Shuttle missions and shows promise for wound healing applications
of benefit to Space Station astronauts.
Effects of Skin-Contact Monochromatic Infrared Irradiation on Tendonitis, Capsulitis, and
Myofascial Pain*
Abstract: Skin-Contact monochromatic infrared irradiation has recently become available
via adaptation of superluminous diode technology. Crainiofacial and cervical myalgias,
insertion tendonitis, and dysfunctions of the temporomandibular joints are addressed. This
article attempts to establish protocol guidelines and report patient responses to this very
effective, noninvasive, physiotherapeutic treatment modality. Both surgical and nonsurgical
cases are reported, and clinical application as well as home unit use is evaluated. Details
on technique are given, and contraindications are outlined. Particular advantages are rapid
patient response, operator-friendly technique, diversity of application parameters, and the
opportunity to manage both acute and chronic conditions in the absence of oral or
injectable pharmacology.
Myofascial Pain*
Abstract: Skin-Contact monochromatic infrared irradiation has recently become available
via adaptation of superluminous diode technology. Crainiofacial and cervical myalgias,
insertion tendonitis, and dysfunctions of the temporomandibular joints are addressed. This
article attempts to establish protocol guidelines and report patient responses to this very
effective, noninvasive, physiotherapeutic treatment modality. Both surgical and nonsurgical
cases are reported, and clinical application as well as home unit use is evaluated. Details
on technique are given, and contraindications are outlined. Particular advantages are rapid
patient response, operator-friendly technique, diversity of application parameters, and the
opportunity to manage both acute and chronic conditions in the absence of oral or
injectable pharmacology.
Symptomatic Reversal of Peripheral Neuropathy in Patients with Diabetes
Abstract: Forty-nine consecutive subjects with established diabetic peripheral neuropathy
were treated with monochromatic near-infrared photo energy (MIRE) to determine if there
was an improvement of sensation. Loss of protective sensation characterized by
Semmes-Weinstein monofilament values of 4.56 and above was present in 100% of
subjects (range, 4.56 to 6.45), and 42 subjects (86%) had Semmes-Weinstein values of
5.07 or higher. The ability to discriminate between hot and cold sensation was absent
(54%) or impaired (46%) in both groups prior to the initiation of MIRE treatment. On the
basis of Semmes-Weinstein monofilament values, 48 subjects (98%) exhibited improved
sensation after 6 treatments,and all subjects had improved sensation after 12 treatments.
Therefore, MIRE may be a safe, drug-free, noninvasive treatment for the consistent and
predictable improvement of sensation in diabetic patients with peripheral neuropathy of the
feet. (J Am Podiatr Med Assoc 92(3): 125-130, 2002)
Abstract: Forty-nine consecutive subjects with established diabetic peripheral neuropathy
were treated with monochromatic near-infrared photo energy (MIRE) to determine if there
was an improvement of sensation. Loss of protective sensation characterized by
Semmes-Weinstein monofilament values of 4.56 and above was present in 100% of
subjects (range, 4.56 to 6.45), and 42 subjects (86%) had Semmes-Weinstein values of
5.07 or higher. The ability to discriminate between hot and cold sensation was absent
(54%) or impaired (46%) in both groups prior to the initiation of MIRE treatment. On the
basis of Semmes-Weinstein monofilament values, 48 subjects (98%) exhibited improved
sensation after 6 treatments,and all subjects had improved sensation after 12 treatments.
Therefore, MIRE may be a safe, drug-free, noninvasive treatment for the consistent and
predictable improvement of sensation in diabetic patients with peripheral neuropathy of the
feet. (J Am Podiatr Med Assoc 92(3): 125-130, 2002)
Therapeutic Light
By Chukuka S. Enwemeka, PT, PhD, FACSM
"Light is a form of energy that behaves like a wave and also as a stream of particles called
photons. The development of monochromatic light sources with single or a narrow spectra
of wavelengths paved the way for studies, which continue to show that appropriate doses
and wavelengths of light are therapeutically beneficial in tissue repair and pain control.
Evidence indicates that cells absorb photons and transform their energy into adenosine
triphosphate (ATP), the form of energy that cells utilize. The resulting ATP is then used to
power metabolic processes; synthesize DNA, RNA, proteins, enzymes, and other products
needed to repair or regenerate cell components; foster mitosis or cell proliferation; and
restore homeostasis."
By Chukuka S. Enwemeka, PT, PhD, FACSM
"Light is a form of energy that behaves like a wave and also as a stream of particles called
photons. The development of monochromatic light sources with single or a narrow spectra
of wavelengths paved the way for studies, which continue to show that appropriate doses
and wavelengths of light are therapeutically beneficial in tissue repair and pain control.
Evidence indicates that cells absorb photons and transform their energy into adenosine
triphosphate (ATP), the form of energy that cells utilize. The resulting ATP is then used to
power metabolic processes; synthesize DNA, RNA, proteins, enzymes, and other products
needed to repair or regenerate cell components; foster mitosis or cell proliferation; and
restore homeostasis."
Seeing the light. How Light Therapy is Surprising Skeptics and Gaining Converts
"What researchers have found is that low-level light can have a favorable effect on
bursitis, tendonitis, strains, sprains, and chronic inflammation. They've found as well that
it promotes faster wound healing and appreciable reductions in pain."
"What researchers have found is that low-level light can have a favorable effect on
bursitis, tendonitis, strains, sprains, and chronic inflammation. They've found as well that
it promotes faster wound healing and appreciable reductions in pain."
Mitochondrial signal transduction in accelerated wound and retinal healing by near-
infrared light therapy
Abstract: Photobiomodulation by light in the red to near infrared range (630–1000 nm)
using low energy lasers or light-emitting diode (LED) arrays has been shown to accelerate
wound healing, improve recovery from ischemic injury in the heart and attenuate
degeneration in the injured optic nerve. Recent evidence indicates that the therapeutic
effects of red to near infrared light result, in part, from intracellular signaling mechanisms
triggered by the interaction of NIR light with the mitochondrial photoacceptor molecule
cytochrome c oxidase. We have demonstrated that NIR-LED photo-irradiation increases
the production of cytochrome oxidase in cultured primary neurons and reverses the
reduction of cytochrome oxidase activity produced by metabolic inhibitors. We have also
shown that NIR-LED treatment prevents the development of oral mucositis in pediatric
bone marrow transplant patients. Photobiomodulation improves wound healing in
genetically diabetic mice by upregulating genes important in the promotion of wound
healing. More recent studies have provided evidence for the therapeutic benefit of NIR
LED treatment in the survival and functional recovery of the retina and optic nerve in vivo
after acute injury by the mitochondrial toxin, formic acid generated in the course of
methanol intoxication. Gene discovery studies conducted using microarray technology
documented a significant upregulation of gene expression in pathways involved in
mitochondrial energy production and antioxidant cellular protection. These findings provide
a link between the actions of red to near infrared light on mitochondrial oxidative
metabolism in vitro and cell injury in vivo. Based on these findings and the strong evidence
that mitochondrial dysfunction is involved in the pathogenesis of numerous diseases
processes, we propose that NIR-LED photobiomodulation represents an innovative and
non-invasive therapeutic approach for the treatment of tissue injury and disease
processes in which mitochondrial dysfunction is postulated to play a role including diabetic
retinopathy, age-related macular degeneration, Leber’s hereditary optic neuropathy and
Parkinson’s disease.
infrared light therapy
Abstract: Photobiomodulation by light in the red to near infrared range (630–1000 nm)
using low energy lasers or light-emitting diode (LED) arrays has been shown to accelerate
wound healing, improve recovery from ischemic injury in the heart and attenuate
degeneration in the injured optic nerve. Recent evidence indicates that the therapeutic
effects of red to near infrared light result, in part, from intracellular signaling mechanisms
triggered by the interaction of NIR light with the mitochondrial photoacceptor molecule
cytochrome c oxidase. We have demonstrated that NIR-LED photo-irradiation increases
the production of cytochrome oxidase in cultured primary neurons and reverses the
reduction of cytochrome oxidase activity produced by metabolic inhibitors. We have also
shown that NIR-LED treatment prevents the development of oral mucositis in pediatric
bone marrow transplant patients. Photobiomodulation improves wound healing in
genetically diabetic mice by upregulating genes important in the promotion of wound
healing. More recent studies have provided evidence for the therapeutic benefit of NIR
LED treatment in the survival and functional recovery of the retina and optic nerve in vivo
after acute injury by the mitochondrial toxin, formic acid generated in the course of
methanol intoxication. Gene discovery studies conducted using microarray technology
documented a significant upregulation of gene expression in pathways involved in
mitochondrial energy production and antioxidant cellular protection. These findings provide
a link between the actions of red to near infrared light on mitochondrial oxidative
metabolism in vitro and cell injury in vivo. Based on these findings and the strong evidence
that mitochondrial dysfunction is involved in the pathogenesis of numerous diseases
processes, we propose that NIR-LED photobiomodulation represents an innovative and
non-invasive therapeutic approach for the treatment of tissue injury and disease
processes in which mitochondrial dysfunction is postulated to play a role including diabetic
retinopathy, age-related macular degeneration, Leber’s hereditary optic neuropathy and
Parkinson’s disease.
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Stationary Vs. Non-Stationary Ultrasound
Mark Schafer, Ph.D.
Chairman of the Technical Standards Committee of the American Institute of
Ultrasound in Medicine (AIUM)
Mark Schafer, Ph.D.
Chairman of the Technical Standards Committee of the American Institute of
Ultrasound in Medicine (AIUM)
